Monday, 23 March 2020

Hope Beyond Coronavirus - a short message from Roger Carswell




He Giveth More Grace

He giveth more grace when the burdens grow greater;
He sendeth more strength when the labours increase.
To added affliction He addeth His mercy;
To multiplied trials, His multiplied peace.

Refrain:
His love has no limit, His grace has no measure,
His pow'r has no boundary known unto men;
For out of His infinite riches in Jesus,
He giveth, and giveth, and giveth again!

When we have exhausted our store of endurance,
When our strength has failed ere the day is half done,
When we reach the end of our hoarded resources,
Our Father's full giving is only begun.

Annie Johnson Flint, 1866-1932.

Monday, 9 March 2020

From the 25% ME Group: 25 year anniversary of the 25% ME Group

https://25megroup.org/25-year-anniversary-of-the-25-me-group

by Simon Lawrence

This year marks the 25 year anniversary of the 25% ME Group, the only charity concerned specifically with the needs of the severely affected.

From the downloadable document  

This year marks the 25 year anniversary of the 25% ME Group, the only charity concerned specifically with the needs of the severely affected.

They have a wealth of experience and as such are generally seen as an authority on Severe ME. The charity has been active in campaigning for better diagnosis, treatment and care of people with Severe ME including being a stakeholder in the NICE review, supporting use of ICC, undertaking surveys about various aspects of Severe ME, disseminating information, etc, and being a respected voice for people who are the most affected by ME. https://25megroup.org/about-us

As part of their 25 year celebrations, and to mark Severe ME Awareness Day on 8 August, 25% ME Group have invited members of the charity and the 25% ME Facebook group to participate in a project to make Severe ME visible. They have been asked to submit Stories and Images of their lives with Severe ME. https://25megroup.org/severe-me-day-2020

For further information, go to –



Tuesday, 3 March 2020

I have chosen thee in the furnace of affliction

http://bible.christiansunite.com/Morning_and_Evening/chme0303.shtml

C H Spurgeon's Morning Devotional for 3rd March

“I have chosen thee in the furnace of affliction.”

Isaiah 48:10

Comfort thyself, tried believer, with this thought: God saith, "I have chosen thee in the furnace of affliction." Does not the word come like a soft shower, assuaging the fury of the flame? Yea, is it not an asbestos armour, against which the heat hath no power? Let affliction come-God has chosen me. Poverty, thou mayst stride in at my door, but God is in the house already, and He has chosen me. Sickness, thou mayst intrude, but I have a balsam ready-God has chosen me. Whatever befalls me in this vale of tears, I know that He has "chosen" me. If, believer, thou requirest still greater comfort, remember that you have the Son of Man with you in the furnace. In that silent chamber of yours, there sitteth by your side One whom thou hast not seen, but whom thou lovest; and ofttimes when thou knowest it not, He makes all thy bed in thy affliction, and smooths thy pillow for thee. Thou art in poverty; but in that lovely house of thine the Lord of life and glory is a frequent visitor. He loves to come into these desolate places, that He may visit thee. Thy friend sticks closely to thee. Thou canst not see Him, but thou mayst feel the pressure of His hands. Dost thou not hear His voice? Even in the valley of the shadow of death He says, "Fear not, I am with thee; be not dismayed, for I am thy God." Remember that noble speech of Caesar: "Fear not, thou carriest Caesar and all his fortune." Fear not, Christian; Jesus is with thee. In all thy fiery trials, His presence is both thy comfort and safety. He will never leave one whom He has chosen for His own. "Fear not, for I am with thee," is His sure word of promise to His chosen ones in the "furnace of affliction." Wilt thou not, then, take fast hold of Christ, and say - 

"Through floods and flames, if Jesus lead,
I'll follow where He goes."

Monday, 2 March 2020

Cerebral blood flow is reduced in ME/CFS during head-up tilt testing

https://www.sciencedirect.com/science/article/pii/S2467981X20300044

Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography

Highlights

• Doppler imaging to measure cerebral blood flow is feasible during tilt testing.

• Cerebral blood flow in ME/CFS patients is reduced during tilt testing.

• 90% of ME/CFS patients show abnormal cerebral blood flow reduction on tilt testing.

• Cerebral blood flow reduction correlates with symptoms of orthostatic intolerance.

Abstract

Objective

The underlying hypothesis in orthostatic intolerance (OI) syndromes is that symptoms are associated with cerebral blood flow (CBF) reduction. Indirect CBF measurements (transcranial Doppler flow velocities), provide inconsistent support of this hypothesis. The aim of the study was to measure CBF during a 30 min head-up tilt test (HUT), using Doppler flow imaging of carotid and vertebral arteries, in individuals with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS), a condition with a high prevalence of OI.

Methods

429 ME/CFS patients were studied: 247 had a normal heart rate (HR) and blood pressure (BP) response to HUT, 62 had delayed orthostatic hypotension (dOH), and 120 had postural orthostatic tachycardia syndrome (POTS). We also studied 44 healthy controls (HC). CBF measurements were made at mid-tilt and end-tilt. Before mid-tilt, we administered a verbal questionnaire to ascertain for 15 OI symptoms.

Results

End-tilt CBF reduction was 7% in HC versus 26% in the overall ME/CFS group, 24% in patients with a normal HR/BP response, 28% in those with dOH, and 29% in POTS patients (all P < .0005). Using a lower limit of normal of 2SD of CBF reduction in HC (13% reduction), 82% of patients with normal HR/BP response, 98% with dOH and 100% with POTS showed an abnormal CBF reduction. There was a linear correlation of summed OI symptoms with the degree of CBF reduction at mid-tilt (P < .0005).

Conclusions

During HUT, extracranial Doppler measurements demonstrate that CBF is reduced in ME/CFS patients with POTS, dOH, and even in those without HR/BP abnormalities.

Significance

This study shows that orthostatic intolerance symptoms are related to CBF reduction, and that the majority of ME/CFS patients (90%) show an abnormal cerebral flow reduction during orthostatic stress testing. This may have implications for the diagnosis and treatment of ME/CFS patients.